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paracetamol + morphine + tramadol
- Development stage
- Phase 4
- Lead developer
- Assistance publique - Hôpitaux de Paris
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Paracetamol + morphine + tramadol is a multimodal analgesic combination regimen being evaluated for the management of pain during vaso-occlusive crises (VOC) in adult patients with sickle cell disease. This combination combines paracetamol (acetaminophen), a non-opioid analgesic and antipyretic, with morphine, a strong mu-opioid receptor agonist, and tramadol, a weak mu-opioid agonist and monoamine reuptake inhibitor. By combining these agents with different mechanisms of action, the regimen aims to optimize pain control and reduce overall morphine consumption, thereby minimizing dose-dependent opioid side effects such as respiratory depression, sedation, and constipation.
- Other names
- acetaminophen + morphine + tramadol
02
Targets
DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)PGHS-1 (Prostaglandin G/H Synthase 1)
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