Drug intelligence / Profile preview

paracetamol + phenylephrine + pheniramine + ascorbic acid

Development stage
Preclinical
Lead developer
GSK
Modality
Small Molecules
Administration
Oral
01

Overview

This combination drug contains **paracetamol** (an analgesic and antipyretic that inhibits central prostaglandin synthesis to reduce pain and fever), **phenylephrine** (a sympathomimetic and alpha-adrenergic agonist acting as a nasal decongestant), **pheniramine** (an antihistamine that blocks H1 histamine receptors to relieve allergy symptoms such as sneezing, runny nose, and watery eyes), and **ascorbic acid** (vitamin C, an antioxidant included to compensate for increased needs during infection and to support immune function). The combination is formulated for the short-term treatment of symptoms associated with colds, influenza, and upper respiratory tract infections, such as headache, body aches, fever, nasal congestion, sneezing, and rhinorrhea[1][3][4][7].

Brand names
TherafluBIACOLDParmabic Hcl Tablets
Other names
Paracetamol, Phenylephrine, Pheniramine Maleate, Ascorbic Acid powder for oral solutionParacetamol, Ascorbic Acid, Phenylephrine Hydrochloride, Pheniramine Maleate Effervescent Tablets
02

Targets

ADRA1A (α1A)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)COX

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