Drug intelligence / Profile preview

paracetamol + pseudoephedrine + triprolidine

Development stage
Unknown
Lead developer
LIFEPharma
Modality
Small Molecules
Administration
Oral
01

Overview

Coldifed-P is a combination pharmaceutical product developed and manufactured by LIFEPharma. It is indicated for the symptomatic relief of the common cold, cough, and flu-like symptoms. The formulation typically contains paracetamol (an analgesic and antipyretic), pseudoephedrine (a nasal decongestant), and triprolidine (an antihistamine). Paracetamol works by inhibiting prostaglandin synthesis in the central nervous system. Pseudoephedrine acts as a sympathomimetic agent on alpha-adrenergic receptors to reduce nasal congestion. Triprolidine is a first-generation H1-receptor antagonist that reduces allergic symptoms such as sneezing and runny nose.

Brand names
Coldifed-P
Other names
Coldifed-P
02

Targets

HTR7 (5-hydroxytryptamine receptor 7)ADRA2A (α2A)CNR1 (Cannabinoid receptor 1)HRH1 (Histamine H1 Receptor)NET (Norepinephrine Transporter)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)TRPV1 (Transient receptor potential cation channel subfamily V member 1)ADRA1A (α1A)

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