paracetamol + pseudoephedrine hydrochloride + dextromethorphan hydrobromide + chlorpheniramine maleate

This combination drug contains four active ingredients: **paracetamol (acetaminophen)**, a pain reliever and fever reducer; **pseudoephedrine hydrochloride**, a sympathomimetic decongestant; **dextromethorphan hydrobromide**, a non-opioid cough suppressant; and **chlorpheniramine maleate**, a first-generation antihistamine. It is used to relieve symptoms associated with the common cold and flu, such as headache, fever, body aches, cough, sore throat, nasal congestion, runny nose, sneezing, and sinus pressure. Mechanistically, it targets prostaglandin synthesis (paracetamol), adrenergic receptors in nasal mucosa (pseudoephedrine), the cough center in the medulla (dextromethorphan), and histamine H1 receptors (chlorpheniramine)[1][2][3][5].

Brand names

Theraflu Nighttime Maximum StrengthTheraflu Severe Cold and CongestionTylenol Cold + Flu Multi-Action Day/Night Extra StrengthVicks 44 Cold Flu and CoughVicks44 Cold Flu and CoughVicks-44 Cold Flu and CoughRobitussin FluComtrex Nighttime Cold and CoughTriaminic Flu Cough and FeverTheraflu-DVicks Formula 44MEXTRA STRENGTH TYLENOL COLD PLUS FLU MULTI-ACTION DAY/NIGHT

Other names

acetaminophen + pseudoephedrine hydrochloride + dextromethorphan hydrobromide + chlorpheniramine maleateacetaminophen + chlorpheniramine + dextromethorphan + pseudoephedrine