paracetamol + tramadol hydrochloride

Shiliqi is a fixed-dose combination analgesic containing paracetamol (acetaminophen) and tramadol hydrochloride. Developed by Shaanxi Jiuzhou Pharmaceutical, it is a generic version of the reference drug ULTRACET, indicated for the management of moderate to severe acute pain. Tramadol hydrochloride is a centrally acting synthetic opioid analgesic that exerts its effect through mu-opioid receptor agonism and the inhibition of the reuptake of norepinephrine and serotonin. Paracetamol is a non-opioid, non-salicylate analgesic and antipyretic that likely acts by inhibiting prostaglandin synthesis in the central nervous system. The combination of these two agents provides a multi-modal approach to pain management, offering rapid onset from paracetamol and sustained relief from tramadol.

Brand names

Shiliqi

Other names

acetaminophen + tramadol hydrochlorideTramadol Hydrochloride and Paracetamol Tablets