Drug intelligence / Profile preview

ParActin

Development stage
Phase 2
Lead developer
HP Ingredients
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

ParActin is a **proprietary, patented, standardized extract** of the plant *Andrographis paniculata*, containing andrographolide, 14-deoxyandrographolide, and neoandrographolide as principal active ingredients. This extract is designed to **support healthy inflammatory responses, joint, cartilage, bone, muscle, and immune health**. Its mechanism centers on inhibiting **NF-kappa B** (a master regulator of inflammation) and activating the **PPAR gamma receptor**, both of which are implicated in the regulation of pro-inflammatory cytokines and proteins. ParActin is marketed primarily as a **dietary supplement** and is not FDA-approved as a pharmaceutical drug. It is available in oral and topical formulations, and has been studied for its potential effects on pain, inflammation, and autoimmune disease. Clinical evidence primarily supports use for mild to moderate joint pain, musculoskeletal discomfort, and inflammatory conditions, but broader claims require further study[1][2][3][4][6].

Brand names
ParActinQuantumActiv ParActinParActin Joint
Other names
Andrographis paniculata extract (standardized to andrographolide, 14-deoxyandrographolide, and neoandrographolide)
02

Targets

CaV (Voltage-gated calcium channel protein complex)NF-κBPPARG (Peroxisome proliferator-activated receptor gamma)

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