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paramethasone

Development stage: Unknown
Modality: Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration: Oral, Topical, Intraarticular, Intralesional

Overview

Paramethasone is a synthetic fluorinated glucocorticoid with potent anti-inflammatory and immunosuppressant properties. It acts as an agonist of the glucocorticoid receptor. Paramethasone inhibits leukocyte infiltration at sites of inflammation and interferes with mediators of the inflammatory response by inducing phospholipase A2 inhibitory proteins (lipocortins), which control the biosynthesis of prostaglandins and leukotrienes. It also suppresses humoral immune responses by reducing cytokine production (notably IL-2) and limiting T cell proliferation. Paramethasone is used to treat various inflammatory or allergic conditions that respond to glucocorticoids[1][2][4][5].

Brand names: HaldroneCortidene
Other names: (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Targets

GR (Glucocorticoid receptor)PLA2 (Phospholipase A2 group IID)

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