Drug intelligence / Profile preview

Parcel

Development stage
Unknown
Lead developer
Novartis
Modality
Small Molecules
Administration
Oral
01

Overview

**Parcel** is an oral fixed-dose analgesic and antimigraine product containing dihydroergotamine mesylate, paracetamol, and caffeine. Dihydroergotamine is an ergot-derived serotonergic agonist that promotes cranial vasoconstrictive antimigraine activity; paracetamol provides analgesia; and caffeine acts as an analgesic adjuvant. Each coated tablet contains dihydroergotamine mesylate 1 mg, paracetamol 450 mg, and caffeine 40 mg. It has been used for symptomatic treatment of headache and migraine and was evaluated in a Phase 3 non-inferiority study in tension-type headache. ([consultaremedios.com.br](https://consultaremedios.com.br/parcel/bula))

Brand names
Parcel
Other names
cafeína + mesilato de diidroergotamina + paracetamoldihydroergotamine mesylate + paracetamol + caffeine
02

Targets

ADORA1 (Adenosine receptor A1 subtype)ADORA2A (Adenosine A₂A Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)HTR1B (5-Hydroxytryptamine Receptor 1B)HTR1D (5-hydroxytryptamine receptor 1D)

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