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pardoprunox
- Development stage
- Phase 3
- Lead developer
- Abbott
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pardoprunox is an investigational small molecule drug developed primarily for the treatment of Parkinson's disease. It acts as a partial agonist at dopamine D2 and D3 receptors and as a full agonist at serotonin 5-HT1A receptors. Pardoprunox also exhibits lower affinity binding to dopamine D4, alpha-1 adrenergic, alpha-2 adrenergic, and serotonin 5-HT7 receptors. Its pharmacological profile was designed to provide antiparkinsonian effects with potentially fewer dopaminergic side effects such as dyskinesia and psychosis compared to other agents in its class. The drug reached phase III clinical trials for Parkinson's disease but development was discontinued before approval. It was also investigated for depression and anxiety but these indications were not pursued further[1][2][3][4][5].
- Other names
- pardoprunox hydrochloride
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR7 (5-hydroxytryptamine receptor 7)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)DRD4 (Dopamine D4 Receptor)ADRA1A (α1A)ADRA2A (α2A)
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