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parental PANC1 vaccine
- Development stage
- Preclinical
- Lead developer
- Osaka University
- Modality
- Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Parenteral
01
Overview
The parental PANC1 vaccine is an experimental whole-cell cancer vaccine composed of irradiated, unmodified PANC1 human pancreatic cancer cells. PANC1 is a human epithelial carcinoma cell line derived from a pancreatic ductal adenocarcinoma. This vaccine is designed to present a broad array of tumor-associated antigens, such as MUC1, to the host immune system to elicit a polyclonal T-cell and B-cell response against pancreatic cancer cells. In research settings, it is frequently utilized as a baseline or control treatment to compare against genetically engineered variants, such as α-gal-modified PANC1 cells, which are designed to be more immunogenic by exploiting natural anti-Gal antibodies to enhance antigen uptake and presentation by antigen-presenting cells (APCs).
- Other names
- irradiated PANC1 cellsPANC-1 vaccinePANC1 vaccinePANC 1 vaccineparental PANC1
02
Targets
MUC1 (Mucin-1 Antigen)Multiple PANC-1-derived tumor-associated antigens and neoantigensPRR (Pattern recognition receptors)
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