paricalcitol

Paricalcitol is a synthetic vitamin D analog used to treat and prevent secondary hyperparathyroidism in patients with chronic kidney disease, particularly those on dialysis. It works by selectively activating the vitamin D3 receptor, which leads to inhibition of parathyroid hormone (PTH) synthesis and secretion. This helps regulate calcium and phosphorus levels in the blood, reducing complications associated with chronic kidney disease. Paricalcitol is available as oral capsules and intravenous solutions[1][2][3][5]. The drug was developed as a modification of calcitriol (the active form of vitamin D), specifically designed to minimize side effects such as hypercalcemia while effectively lowering PTH levels[2][6]. Its primary indication is for secondary hyperparathyroidism due to chronic renal failure.

Brand names

Zemplar

Other names

19-nor-1,25-dihydroxyvitamin D2