Drug intelligence / Profile preview

parietaria judaica pollen depigmented polymerized extract

Development stage
Unknown
Lead developer
Leti Pharma
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

Parietaria judaica pollen depigmented polymerized extract is a chemically modified allergen immunotherapy (allergoid) developed by Laboratorios LETI for the treatment of allergic rhinoconjunctivitis and episodic allergic asthma. The product is derived from *Parietaria judaica* pollen, which is processed through acid treatment to remove pigments and then polymerized with glutaraldehyde. This chemical modification reduces the extract's allergenicity (IgE-binding capacity) while preserving its immunogenicity, allowing for a safer and more rapid subcutaneous immunotherapy (SCIT) dosing schedule. It is marketed under the brand name Depigoid and has been evaluated in Phase 3 clinical trials.

Brand names
Depigoid
Other names
Parietaria judaica allergoiddepigmented polymerized Parietaria judaica extract
02

Targets

TCR (T cell antigen receptor complex)Parietaria judaica-specific immunoglobulin E (Par j-sIgE)

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