Drug intelligence / Profile preview

paritaprevir + ritonavir + ombitasvir + peginterferon alfa-2a + ribavirin

Development stage
Unknown
Lead developer
AbbVie
Modality
Small Molecules, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Recombinant Proteins and Enzymes, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration
Oral, Subcutaneous
01

Overview

This drug is a five-component combination regimen consisting of **paritaprevir**, **ritonavir**, **ombitasvir**, **peginterferon alfa-2a**, and **ribavirin**. It is used for the treatment of chronic hepatitis C virus (HCV) infection, particularly in patients with genotype 1 or 4, though differences in regimen components exist by genotype and country. Paritaprevir is an HCV NS3/4A protease inhibitor; ritonavir is a CYP3A inhibitor used here as a pharmacokinetic enhancer to boost paritaprevir levels; ombitasvir is an HCV NS5A inhibitor; peginterferon alfa-2a is a long-acting interferon stimulating antiviral immune responses; and ribavirin is a nucleoside analog with broad-spectrum antiviral activity. This combination acts via multiple mechanisms to inhibit viral replication and enhance immune-mediated clearance of HCV. Peginterferon and ribavirin were previously standard HCV therapies and are sometimes added to direct-acting antiviral regimens, particularly in patients with more advanced disease or specific genotypes.

02

Targets

NS5A (Hepatitis C virus nonstructural protein 5A (genotype 1b))vRNA (Coronavirus viral RNA)CYP3A7 (Cytochrome P450 3A7)NS3/4A (Hepatitis C virus nonstructural protein 3/4A serine protease)IFNAR (Immune system modulation via type I interferon receptor)PR (Progesterone receptor)

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