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PARP7 inhibitor is a small molecule therapeutic being developed by Angel Pharmaceuticals for the treatment of various cancers. PARP7, also known as TCDD-inducible poly [ADP-ribose] polymerase (TIPARP), is a mono-ADP-ribosyltransferase that acts as a negative regulator of the type I interferon (IFN) response. By inhibiting PARP7, this drug aims to restore interferon signaling within the tumor microenvironment, thereby enhancing the innate immune system's ability to recognize and attack cancer cells. The program is currently in the preclinical stage of development, and while the specific chemical entity name has not been disclosed, it represents a targeted approach to oncology by modulating the immune response within cancer cells.
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