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Passiflora cincinnata extract is a botanical extract derived from the Brazilian native passionflower *Passiflora cincinnata* Mast., primarily found in the Caatinga biome. The extract, often prepared as an ethanolic solution from leaves or aerial parts, is rich in C-glycoside flavonoids such as vitexin, isovitexin, orientin, and isoorientin. Preclinical research has demonstrated its potential neuroprotective effects in Parkinson's disease models, where it appears to delay motor symptoms and prevent the loss of dopaminergic neurons in the substantia nigra. Its pharmacological profile suggests involvement with opioid and muscarinic receptors, potassium channels, and the nitric oxide pathway, contributing to antinociceptive and anti-inflammatory activities. It is currently studied in academic research settings and is not yet a commercial pharmaceutical product.
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