Drug intelligence / Profile preview

passiflora incarnata dry extract

Development stage
Unknown
Lead developer
Tilman
Administration
Oral
01

Overview

Tractamed (passiflora incarnata dry extract) is an approved traditional herbal medicine developed by Tilman and marketed in Italy by Laboratori Baldacci. It is formulated as 500 mg film-coated tablets containing a standardized dry extract of *Passiflora incarnata* L. (passion flower). Tractamed is indicated for the relief of mild symptoms of mental stress, such as nervousness, anxiety, or irritability, and to facilitate sleep. The therapeutic effects of *Passiflora incarnata* are primarily mediated through the modulation of the central GABAergic system. Active constituents, including flavonoids such as chrysin and apigenin, act as positive allosteric modulators of the GABA-A receptor and antagonists of the GABA-B receptor, while also inhibiting GABA reuptake, thereby enhancing inhibitory neurotransmission in the central nervous system.

Brand names
AnxemilBlossominSedistressSedistress forteSedix forteSedizinTractamedTractanaZenaxal
Other names
passiflora extractpassiflora incarnata dry extractpassiflora incarnata extractpassion flower extractpassionflower extract
02

Targets

GABRR (GABA-A receptor subunit rho)SLC6A1 (Sodium- and chloride-dependent GABA transporter 1)GABA-B (Gamma-aminobutyric acid receptor type B)

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