Drug intelligence / Profile preview

PastoCovac

Development stage
Unknown
Lead developer
Finlay Vaccine Institute
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

PastoCovac is a protein subunit conjugate vaccine developed for the prevention of COVID-19 through a collaboration between the Finlay Institute of Vaccines in Cuba and the Pasteur Institute of Iran. The vaccine is based on a recombinant version of the SARS-CoV-2 spike protein's receptor-binding domain (RBD), which is chemically conjugated to a tetanus toxoid carrier protein and adsorbed onto aluminum hydroxide. This conjugation strategy is designed to enhance the immunogenicity of the RBD antigen by recruiting T-cell help, thereby stimulating a more robust and durable immune response compared to the antigen alone. It is typically administered as a two-dose primary series, often followed by a booster dose of a related vaccine, such as PastoCovac Plus (Soberana Plus), to maintain high levels of neutralizing antibodies.

Brand names
PastoCovacSoberana 02Soberana02Soberana-02
Other names
Soberana 02Soberana02Soberana-02RBD-tetanus toxoid conjugate vaccine
02

Targets

SARS-CoV-2 spike

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