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Patient-controlled analgesia

Development stage
Unknown
Modality
Small Molecules
01

Overview

This patient-controlled analgesia (PCA) regimen is a multimodal postoperative pain management protocol utilized by the Medical College of Wisconsin for patients undergoing robot-assisted anatomic lung resection. The regimen consists of a combination of oral medications, including the non-opioid analgesic acetaminophen (Tylenol), the skeletal muscle relaxant methocarbamol (Robaxin), and the opioid analgesic tramadol. In the context of clinical trials at Froedtert Hospital, this protocol serves as the standard-of-care control arm. While PCA traditionally refers to intravenous delivery systems, this specific protocol emphasizes a transition to oral analgesics supplemented by a baseline intercostal nerve block (bupivacaine with epinephrine) provided to all surgical patients to optimize recovery and minimize opioid consumption.

Other names
PCAPatient-controlled analgesiaStandard PCA (Froedtert Hospital)
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)MOR (Mu opioid receptor)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)

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