Drug intelligence / Profile preview

patient controlled intravenous analgesia-Gaziosmanpasa Research and Education Hospital

Development stage
Unknown
Lead developer
Gaziosmanpaşa Training and Research Hospital
Modality
Small Molecules
Administration
Intravenous
01

Overview

This refers to a specific postoperative analgesic protocol utilizing patient-controlled intravenous analgesia (PCIA) with tramadol, as implemented in clinical research at Gaziosmanpasa Research and Education Hospital. Tramadol is a centrally acting synthetic opioid analgesic that exerts its effects through a dual mechanism of action: it acts as a weak agonist at mu-opioid receptors and inhibits the neuronal reuptake of norepinephrine and serotonin. In the context of the hospital's protocol (e.g., for laparoscopic cholecystectomy), the PCIA regimen typically involves a 20 mg bolus of intravenous tramadol with a 20-minute lockout time, a 4-hour limit of 100 mg, and a 24-hour limit of 400 mg. This method allows patients to self-administer small doses of analgesia to manage acute postoperative pain effectively.

Other names
PCIA-tramadolpatient-controlled intravenous analgesia with tramadol
02

Targets

MOR (Mu opioid receptor)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)

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