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Payayor Glycerine Preparation is a topical herbal medicine developed by Chaopraya Abhaibhubejhr Hospital in Thailand. The formulation contains an extract of *Clinacanthus nutans* (Burm. f.) Lindau, a plant traditionally used in Southeast Asia for its medicinal properties. The preparation is specifically designed for application to the oral mucosa to treat oral herpes (herpes simplex virus infections) and aphthous ulcers (mouth sores). It is also utilized to manage mouth sores in cancer patients undergoing radiation or chemotherapy (mucositis). The active components of *Clinacanthus nutans* exhibit potent antiviral activity by interfering with viral attachment and penetration, particularly against HSV-1 and HSV-2, and possess anti-inflammatory properties that aid in the healing of mucosal lesions.
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