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Drug intelligence / Profile preview
pazopanib
- Development stage
- Approved
- Lead developer
- GSK
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Pazopanib is an orally administered small molecule antineoplastic agent used primarily for the treatment of advanced renal cell carcinoma and advanced soft tissue sarcoma in adults who have received prior chemotherapy. It acts as a second-generation, multitargeted tyrosine kinase inhibitor, selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3), platelet-derived growth factor receptors (PDGFR-alpha and PDGFR-beta), and c-kit. By blocking these targets involved in angiogenesis pathways, pazopanib reduces tumor blood vessel formation necessary for tumor survival and growth. Pazopanib was originally developed by GlaxoSmithKline and is now marketed worldwide by Novartis under the brand name Votrient[1][4][5][6].
- Brand names
- Votrient
- Other names
- pazopanib hydrochloride
02
Targets
BRAF (B-Raf proto-oncogene, serine/threonine kinase)CSF1R (Macrophage colony-stimulating factor receptor)FGFR1 (Fibroblast growth factor receptor 1)FLT3 (Fms related receptor tyrosine kinase 3)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)
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