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pazopanib + trabectedin + ipilimumab + nivolumab
- Development stage
- Phase 1
- Lead developer
- University of Texas MD Anderson Cancer Center
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
pazopanib + trabectedin + ipilimumab + nivolumab is an experimental combination therapy regimen being evaluated in the TraPIN Phase I clinical trial (NCT04356807) at the M.D. Anderson Cancer Center. This multi-modal approach targets recurrent soft tissue sarcomas in pediatric and young adult patients by combining the anti-angiogenic and anti-proliferative effects of pazopanib (a multi-kinase inhibitor), the DNA-binding cytotoxic activity of trabectedin, and dual immune checkpoint blockade with ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1). The study aims to determine the safety and recommended Phase II dose of this intensive combination, building upon the SAINT trial's chemotherapy-immunotherapy backbone by adding a targeted tyrosine kinase inhibitor to enhance efficacy in refractory sarcoma populations.
- Other names
- TraPIN regimen
02
Targets
BRAF (B-Raf proto-oncogene, serine/threonine kinase)CSF1R (Macrophage colony-stimulating factor receptor)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)FGFR1 (Fibroblast growth factor receptor 1)FGFR3 (Fibroblast growth factor receptor 3)FLT3 (Fms related receptor tyrosine kinase 3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDCD1 (Programmed cell death protein 1 receptor)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)DNA
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