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PB-012
- Development stage
- Unknown
- Lead developer
- Primo Biotechnology
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
PB-012 is a gallium-68 (68Ga) labeled radiopharmaceutical developed by Primo Biotechnology for the diagnostic imaging of metastatic colorectal cancer. It specifically targets Folate Hydrolase 1 (FOLH1), also known as Prostate-Specific Membrane Antigen (PSMA). Although PSMA is a well-established marker in prostate cancer, it is also highly expressed in the neovasculature of various other solid tumors, including colorectal cancer. PB-012 is designed as a PET imaging agent to identify FOLH1-positive metastatic lesions, which can assist in patient stratification and the monitoring of disease progression. The drug is currently in Phase 1 clinical development.
- Other names
- 68Ga-PB-012Gallium (68Ga) PB-012
02
Targets
PSMA (Prostate-specific membrane antigen)
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