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Pb-212-RMX PSMA

Development stage: Unknown
Lead developer: Radiomedix
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Pb-212-RMX PSMA is a targeted alpha therapy (TAT) radiopharmaceutical being developed by RadioMedix in collaboration with Vect-Horus for the treatment of prostate cancer. The drug consists of a ligand targeting the prostate-specific membrane antigen (PSMA), which is overexpressed in prostate cancer cells, conjugated to the alpha-emitting radioisotope Lead-212 (Pb-212). By binding to PSMA, the radioligand delivers high-LET (linear energy transfer) alpha radiation directly to the tumor site, inducing complex double-strand DNA breaks that are difficult for cells to repair, thereby promoting cell death while sparing adjacent healthy tissues. It is currently in preclinical development.

Other names: Vect-Horus-PSMAPb-212-RMX PSMA-RadioMedix/Vect-Horus-PSMA

Targets

PSMA (Prostate-specific membrane antigen)

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