Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
PBCAR269B
- Development stage
- Preclinical
- Lead developer
- Precision BioSciences
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
PBCAR269B is an investigational **allogeneic BCMA-directed CAR-T cell therapy** being developed by Precision BioSciences for relapsed or refractory multiple myeloma. It is a next-generation successor to PBCAR269A and is engineered using the company's ARCUS genome editing platform to target **B-cell maturation antigen** on malignant plasma cells while incorporating **stealth cell** features intended to reduce host immune recognition and improve persistence of donor-derived CAR-T cells. The program was described as being in IND-enabling development with plans for IND filing in early 2022, indicating a preclinical-stage off-the-shelf cell therapy designed for antimyeloma immunotherapy.
- Other names
- allogeneic anti-BCMA CAR-T cell therapy
02
Targets
BCMA (B-cell maturation antigen)
Beyond the preview
Go deeper on PBCAR269B.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PBCAR269B.