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PBI-205

Development stage: Preclinical
Lead developer: Protheragen
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

PBI-205 is a preclinical-stage bispecific antibody developed by Protheragen for the treatment of solid tumors. It is designed to simultaneously target Programmed Cell Death Protein 1 (PD-1) and Programmed Death-Ligand 1 (PD-L1). By dual-targeting the PD-1/PD-L1 axis, PBI-205 aims to enhance the blockade of immune checkpoints, potentially overcoming resistance mechanisms associated with monotherapy and improving anti-tumor immune responses. The asset is currently listed as an available project for licensing or co-development by Protheragen.

Other names: PBI-205PBI205PBI 205

Targets

PDCD1 (Programmed cell death protein 1 receptor)CD274 (Programmed cell death protein 1 ligand 1)

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