Drug intelligence / Profile preview

PBL1

Development stage
Unknown
Lead developer
Shanghai University
01

Overview

PBL1: sourced facts only. name: "PBL1 effectively induces PD-L1 degradation both in vitro and in vivo, significantly reducing the off-target toxicity commonly associated with traditional PD-L1 inhibitors." [PMID:40403183]; target: "PBL1 effectively induces PD-L1 degradation both in vitro and in vivo, significantly reducing the off-target toxicity commonly associated with traditional PD-L1 inhibitors." [PMID:40403183]; developer: "School of Medicine or Institute of Translational Medicine, Shanghai Engineering Research Center of Organ Repair, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China." [PMID:40403183]; stage: "The efficacy and specificity of PBL1 have been validated in A549 cells and zebrafish models." [PMID:40403183]

02

Targets

CD274 (Programmed cell death protein 1 ligand 1)

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