Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
PBM-TQ-NP
- Development stage
- Preclinical
- Lead developer
- Morehouse School of Medicine
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
PBM-TQ-NP is an engineered nanoparticle formulation of thymoquinone (TQ), a bioactive constituent derived from *Nigella sativa*. These nanoparticles are synthesized using planetary ball-milling (PBM) technology and feature a starch-based inner core encapsulated within a shell of biocompatible and biodegradable co-polymers, specifically poly(ε-caprolactone) and poly(ethylene glycol) (PCL/PEG). The formulation is designed to overcome the challenges of low bioavailability and poor targeted delivery associated with natural compounds. PBM-TQ-NP is primarily investigated for the treatment of drug-resistant prostate cancer, including metastatic castration-resistant prostate cancer (mCRPC). It exerts its therapeutic effects by modulating cellular and molecular pathways involved in docetaxel resistance, such as the EGFR and ZEB1 signaling axes, and by counteracting ATP-binding cassette (ABC)-transporter-mediated chemoresistance (specifically ABCB1). Additionally, it downregulates key survival and epithelial-mesenchymal transition (EMT) markers, including Akt-1, ERK1/2, NF-kB, and STAT3.
- Other names
- thymoquinone-encapsulated planetary ball-milled nanoparticlesTQ-PBM-NP
02
Targets
ABCB1 (P-glycoprotein)EGFR (Epidermal growth factor receptor)ZEB1 (Zinc finger E-box-binding homeobox 1)
Beyond the preview
Go deeper on PBM-TQ-NP.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PBM-TQ-NP.