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PBM2M3
- Development stage
- Preclinical
- Lead developer
- Shanghai Jiao Tong University School of Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**PBM2M3** is an oral, minocycline-containing bismuth quadruple rescue regimen evaluated for *Helicobacter pylori* infection. It comprises a proton-pump inhibitor component that may be **esomeprazole or vonoprazan**, bismuth potassium citrate 600 mg twice daily, minocycline 50 mg twice daily, and metronidazole 400 mg three times daily. Acid suppression increases intragastric pH and supports antibiotic activity, while bismuth, minocycline, and metronidazole provide complementary anti-*H. pylori* activity. The regimen was studied by Shanghai Jiao Tong University School of Medicine in a real-world rescue-treatment study.
- Other names
- bismuth potassium citrate + minocycline + metronidazole + proton pump inhibitor
02
Targets
ClpX (Caseinolytic mitochondrial matrix peptidase chaperone subunit X)ATP4A (Potassium–transporting ATPase alpha chain 1)Neuraminidase
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