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PBX-CT-02

Development stage: Preclinical
Lead developer: PinotBio
Modality: Nucleic Acid-Directed Small Molecules → Small Molecules, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Intravenous

Overview

PBX-CT-02 is an antibody-drug conjugate (ADC) targeting Nectin-4, under development by Pinotbio. It is being investigated primarily for the treatment of non-small cell lung cancer and solid tumors. The drug acts as a Nectin-4 modulator, though its precise mechanism of action has not been fully defined in public sources. As of March 2025, it remains in preclinical development with no orphan drug designation and is considered a new molecular entity[1][2].

Other names: CT P71

Targets

PVRL4 (Nectin cell adhesion molecule 4)

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