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PC-535 is a carrageenan-based vaginal gel developed by the Population Council to serve as a matching placebo control in clinical trials for microbicides, specifically for the Griffithsin-based gel PC-6500. It is designed to match the active formulation in appearance, viscosity, and composition, excluding the active pharmaceutical ingredient (griffithsin). While carrageenan itself has been studied for potential antiviral properties, in this context, PC-535 functions as an inert control to evaluate the safety, pharmacokinetics, and pharmacodynamics of investigational HIV pre-exposure prophylaxis (PrEP) products in healthy women.
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