pCe6

pCe6 is a synthetic photosensitizer designed for targeted photodynamic therapy (PDT) with a specific focus on the endoplasmic reticulum (ER). It is chemically synthesized by conjugating Chlorin e6 (Ce6), a second-generation photosensitizer, with p-Toluenesulfonamide, which acts as an ER-targeting moiety. By localizing to the ER, pCe6 induces significant ER stress and reactive oxygen species (ROS) production upon light activation, leading to cancer cell apoptosis and immunogenic cell death. In preclinical research, pCe6 has been incorporated into hyaluronic acid-modified nanoplatforms (such as HA/pCe6-Ato NPs) to treat colorectal cancer. This strategy aims to dismantle cancer stemness and reprogram the immunosuppressive tumor microenvironment, thereby enhancing the efficacy of immunotherapy.

Other names

p-Toluenesulfonamide-Chlorin e6 conjugateER-targeting photosensitizer pCe6