PCH4

PCH4 is a synthetic small molecule derivative of N-butylidenephthalide (BP), a natural compound isolated from the medicinal herb *Angelica sinensis*. It is primarily investigated for its potential therapeutic application in malignant brain tumors, specifically glioblastoma multiforme (GBM). PCH4 exerts its antitumor effects by inducing the overexpression and nuclear-to-cytosolic translocation of the orphan receptor Nur77 (NR4A1), which subsequently triggers cell apoptosis. This mechanism is mediated through the activation of the JNK signaling pathway. Research indicates that PCH4 exhibits significantly higher tumor inhibition potency (approximately four times greater) compared to its parent compound, BP, in human glioblastoma cell lines such as DBTRG-05MG.

Other names

(Z)-N-(2-(dimethylamino)ethyl)-2-(3-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)phenoxy)acetamide