Drug intelligence / Profile preview

PCLUS 3-18 MN

Development stage
Phase 1
Lead developer
Genentech
Modality
Peptides, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

PCLUS 3-18 MN is an experimental HIV vaccine candidate composed of synthetic peptides derived from the envelope glycoprotein gp120 of the HIV-1 MN strain. It has been investigated in clinical trials as a potential immunotherapeutic or prophylactic agent for human immunodeficiency virus (HIV) infection. The vaccine aims to elicit an immune response, particularly by inducing neutralizing antibodies and possibly cytotoxic T lymphocyte responses against HIV, thereby preventing or controlling infection. The "MN" designation refers to the specific clade B isolate of HIV-1 used as the antigen source for this formulation[6][9]. Clinical studies have evaluated its safety and immunogenicity in individuals with early-stage HIV infection[9].

02

Targets

Env (HIV-1 envelope glycoprotein)

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