Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
PCN-222-Mn
- Development stage
- Preclinical
- Lead developer
- Nanjing Drum-Tower Hospital
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
PCN-222-Mn (also known as PCN-222(Mn) or Mn-PCN-222) is a manganese-metalloporphyrin metal-organic framework (MOF) nanozyme being developed by Nanjing University and Nanjing Drum Tower Hospital. It is designed to mimic the activities of natural antioxidant enzymes, specifically superoxide dismutase (SOD) and catalase (CAT), to scavenge reactive oxygen species (ROS). PCN-222-Mn is capable of crossing the blood-testis barrier (BTB) via endocytosis and exocytosis, allowing it to protect germ cells and associated somatic cells from chemotherapy-induced testicular injury and preserve male fertility. Additionally, due to the paramagnetic properties of its manganese ions, PCN-222-Mn exhibits high longitudinal relaxivity, enabling its use as a T1-weighted magnetic resonance imaging (MRI) contrast agent for guided delivery and theranostic applications in cancer.
- Other names
- manganese-metalloporphyrin frameworkmanganese-superoxide dismutase mimic
Beyond the preview
Go deeper on PCN-222-Mn.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PCN-222-Mn.