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Drug intelligence / Profile preview
PD-1 antibody-blocked autologous RAK cells
- Development stage
- Unknown
- Lead developer
- Everbright
- Modality
- Cell Therapies
01
Overview
PD-1 antibody-blocked autologous RAK cells are an investigational, patient-specific adoptive cell-therapy approach evaluated in a Phase I study for second-line or later advanced non-small cell lung cancer. RAK cells are autologous RetroNectin-activated killer-cell preparations generated from peripheral-blood mononuclear cells; the trial title indicates that the cells are treated with an unspecified PD-1-blocking antibody to reduce PD-1 checkpoint signaling and potentially augment antitumor cytotoxic immune activity. The specific PD-1 antibody, manufacturing process, and a unique product code or INN were not identified in the public trial registration. ([chictr.org.cn](https://www.chictr.org.cn/showproj.html?proj=62989))
- Other names
- PD-1 antibody-blocked autologous RAK cellsPD1 antibody-blocked autologous RAK cellsPD 1 antibody-blocked autologous RAK cellsPD-1 antibody-blocked autologous RetroNectin-activated killer cellsPD1 antibody-blocked autologous RetroNectin-activated killer cellsPD 1 antibody-blocked autologous RetroNectin-activated killer cells
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)
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