Drug intelligence / Profile preview

PD-1 antibody expressing mesothelin specific CAR-T cells

Development stage: Phase 2
Lead developer: Shanghai Mengchao Cancer Hospital
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

**PD-1 antibody expressing mesothelin specific CAR-T cells** are an investigational autologous engineered T-cell product developed by Ningbo Cancer Hospital with Shanghai University Affiliated Mengchao Cancer Hospital for relapsed or refractory mesothelin-positive advanced solid tumors. The cells express a mesothelin-directed chimeric antigen receptor to recognize and kill mesothelin-expressing tumor cells and are additionally engineered to express or secrete an anti-PD-1 antibody, providing localized PD-1 checkpoint blockade intended to counteract immunosuppression in the solid-tumor microenvironment. The product has been evaluated in the Phase 1/2 study NCT03030001.

Other names: αPD-1-MSLN-CAR-T cellsαPD-1-mesoCAR-T cells

Targets

MesothelinPDCD1 (Programmed cell death protein 1 receptor)

Beyond the preview

Go deeper on PD-1 antibody expressing mesothelin specific CAR-T cells.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on PD-1 antibody expressing mesothelin specific CAR-T cells.

Explore the full profile