PD-1 edited TILs

PD-1 edited TILs are tumor-infiltrating lymphocytes (TILs) that have been genetically modified to disrupt or knock out the PD-1 (programmed cell death protein 1) gene, resulting in reduced PD-1 surface expression. This is achieved through gene-editing technologies such as zinc finger nucleases (ZFN) or CRISPR-Cas9. The purpose of modifying these cells is to enhance their anti-tumor immune activity, as PD-1 normally acts as an inhibitory receptor that suppresses T cell activity in the tumor microenvironment. By removing PD-1, these TILs can bypass tumor-mediated immunosuppression (notably via the PD-1/PD-L1 axis), exhibit enhanced cytokine secretion (including TNFα, GM-CSF, and IFN-γ), and possess increased cytotoxic effector functions. Early studies have demonstrated improved in vitro function and preserved proliferative capacity without negative phenotypic changes. The approach is under investigation primarily for advanced solid tumors, especially metastatic melanoma[2][4][5].

Other names

PD-1 knockout TILsPD1 knockout TILsPD 1 knockout TILsPD-1 gene-edited TILsPD1 gene-edited TILsPD 1 gene-edited TILs