Drug intelligence / Profile preview

PD-616

Development stage
Discontinued
Modality
Small Molecules
Administration
Not Specified (likely Intravenous Or Subcutaneous Based On Typical Aml Therapies, But Not Confirmed)
01

Overview

PD-616 is an investigational drug that has been studied in combination with low-dose cytarabine for the treatment of acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). Preliminary clinical studies indicated that PD-616 is extremely potent in causing a marked and favorable increase in white blood cells. The precise mechanism of action, chemical structure, and molecular target of PD-616 have not been publicly disclosed. The available data suggest it was being evaluated as a potential adjunct to standard chemotherapy to enhance hematopoietic recovery or anti-leukemic efficacy[1][4][9].

Other names
12-O-tetradecanoylphorbol-13-acetatephorbol 12-O-tetradecanoate-13-acetatephorbol12-O-tetradecanoate-13-acetatephorbol-12-O-tetradecanoate-13-acetatephorbol 12-myristate 13-acetatephorbol12-myristate 13-acetatephorbol-12-myristate 13-acetatephorbol myristate acetatePMATPA
02

Targets

PKC (Protein kinase C family)

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