Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
PDA-TFPC-COF
- Development stage
- Preclinical
- Lead developer
- King Fahd University of Petroleum and Minerals
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
PDA-TFPC-COF is a two-dimensional (2D) imine-linked covalent organic framework (COF) synthesized via the Schiff-base condensation of p-phenylenediamine (PDA) and tri(4-formylphenoxy)cyanurate (TFPC). Developed for the localized treatment of chronic wound infections, this biomaterial exhibits inherent broad-spectrum antibacterial activity against both Gram-positive (e.g., Bacillus spp.) and Gram-negative (e.g., Escherichia coli) bacteria. Its mechanism of action is hypothesized to involve bacterial membrane disruption or the generation of reactive oxygen species (ROS). Additionally, the highly porous crystalline structure of PDA-TFPC-COF allows it to function as a drug delivery vehicle for the sustained and controlled release of co-loaded antibiotics, such as ciprofloxacin, thereby enhancing localized antimicrobial efficacy.
- Other names
- PDA-TFPC covalent organic frameworkPDA-TFPC-COFTFPCPa-COF
Beyond the preview
Go deeper on PDA-TFPC-COF.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PDA-TFPC-COF.