Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
PDC-1421
- Development stage
- Phase 2
- Lead developer
- BioLite
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
PDC-1421 is an oral botanical formulation derived from the root of Polygala tenuifolia (Radix polygalae), developed as a potential treatment for major depressive disorder (MDD) and attention-deficit hyperactivity disorder (ADHD). The active pharmaceutical ingredient, also known as Radix polygalae extract, acts primarily as a norepinephrine transporter (NET) inhibitor, thereby modulating norepinephrine reuptake in the brain. This mechanism is associated with antidepressant and sedative effects. Clinical studies have shown that PDC-1421 can significantly reduce depressive symptoms and improve focus in ADHD patients, with a favorable safety profile compared to traditional antidepressants[1][2][3][5][6]. The drug is being developed by BioLite (a subsidiary of ABVC BioPharma), with involvement from several academic institutions.
- Other names
- Radix polygalae extract PDC-1421Polygala tenuifolia Willd. extract
02
Targets
NET (Norepinephrine Transporter)
Beyond the preview
Go deeper on PDC-1421.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on PDC-1421.