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PDC-NPY1R
- Development stage
- Preclinical
- Lead developer
- MolGenie
- Modality
- Peptide-Drug Conjugates → Peptide Conjugates → Peptides
01
Overview
PDC-NPY1R is a preclinical-stage peptide-drug conjugate (PDC) being developed by MolGenie for the treatment of various solid tumors. The therapeutic is designed to target the neuropeptide Y1 receptor (NPY1R), which is frequently overexpressed in several high-risk malignancies and correlates with increased metastatic potential. The conjugate consists of a peptide ligand specific to NPY1R linked to a cytotoxic payload, enabling the selective delivery of the drug directly to cancer cells while minimizing systemic off-target effects. MolGenie acquired the discovery platform for this candidate from OntoChem GmbH. The drug has demonstrated efficacy in patient-derived xenograft (PDX) models of breast cancer and sarcoma and is currently being prepared for formal GLP preclinical studies.
- Other names
- Unnamed PDC candidateNPY1R-peptide-drug conjugateNPY-1R-peptide-drug conjugateNPY 1R-peptide-drug conjugate
02
Targets
NPY1R (Neuropeptide Y receptor Y1)
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