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PDGF-BB + rhPDGF-BB-University of Alabama at Birmingham

Development stage: Preclinical
Lead developer: University of Alabama at Birmingham
Modality: Recombinant Proteins and Enzymes
Administration: Topical

Overview

PDGF-BB + rhPDGF-BB-University of Alabama at Birmingham refers to an experimental research protocol and combination of growth factor sources evaluated by the University of Alabama at Birmingham. This study compares the release kinetics of platelet-derived growth factor-BB (PDGF-BB) derived from autologous platelet-rich fibrin (PRF) against recombinant human PDGF-BB (rhPDGF-BB), specifically the commercial product GEM21S. The combination aims to optimize the concentration and delivery of PDGF-BB in 'sticky bone' preparations using various bone substitutes like beta-tricalcium phosphate (β-TCP), xenografts, and allografts. PDGF-BB acts as a potent mitogen and chemoattractant for cells involved in periodontal wound healing, including osteoblasts and fibroblasts, by activating PDGF receptors to stimulate bone and tissue regeneration.

Brand names: GEM21SGEM-21SGEM 21S
Other names: Platelet-derived growth factor-BBrhPDGF-BBbecaplerminPlatelet-rich fibrin + rhPDGF-BB

Targets

PDGFRB (Platelet-derived growth factor receptor beta)PDGFRA (Platelet-derived growth factor receptor alpha)

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