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PDGF-BB + rhPDGF-BB-University of Alabama at Birmingham
- Development stage
- Phase 3
- Lead developer
- University of Alabama at Birmingham
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Topical
01
Overview
PDGF-BB + rhPDGF-BB-University of Alabama at Birmingham refers to an experimental research protocol and combination of growth factor sources evaluated by the University of Alabama at Birmingham. This study compares the release kinetics of platelet-derived growth factor-BB (PDGF-BB) derived from autologous platelet-rich fibrin (PRF) against recombinant human PDGF-BB (rhPDGF-BB), specifically the commercial product GEM21S. The combination aims to optimize the concentration and delivery of PDGF-BB in 'sticky bone' preparations using various bone substitutes like beta-tricalcium phosphate (β-TCP), xenografts, and allografts. PDGF-BB acts as a potent mitogen and chemoattractant for cells involved in periodontal wound healing, including osteoblasts and fibroblasts, by activating PDGF receptors to stimulate bone and tissue regeneration.
- Brand names
- GEM21SGEM-21SGEM 21S
- Other names
- Platelet-derived growth factor-BBrhPDGF-BBbecaplerminPlatelet-rich fibrin + rhPDGF-BB
02
Targets
PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)
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