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Drug intelligence / Profile preview
PDL1-CD47 dual nanobodies
- Development stage
- Preclinical
- Lead developer
- Shaperon
- Modality
- Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intratumoral, Intraperitoneal, Intravenous
01
Overview
PDL1-CD47 dual nanobodies are a novel class of nanobody-based drugs designed to target both Programmed death-ligand 1 (PDL1) and Cluster of differentiation 47 (CD47) simultaneously. This dual targeting approach aims to enhance anti-tumor immunity by blocking both adaptive and innate immune checkpoints. Developed through a collaboration between Shaperon and Dong-A ST, these nanobodies are being advanced for the treatment of cancer. Shaperon contributes its nanobody development platform, while Dong-A ST provides expertise in antibody commercialization and global biopharmaceutical development. Preclinical results for anti-cancer PDL1-CD47 dual nanobodies have been presented, indicating their technological capabilities.
02
Targets
CD47 (Cluster of Differentiation 47)CD274 (Programmed cell death protein 1 ligand 1)
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