PDV-D

PDV-D is a virus-like protein delivery vehicle platform developed by GenEditBio for the in vivo generation of chimeric antigen receptor (CAR)-T cells. The system encapsulates a complex payload consisting of genome-targeting CRISPR ribonucleoproteins (RNPs) and CAR DNA templates. PDV-D is engineered for T-cell-specific targeting via selective binders and enables site-specific transgene integration downstream of endogenous T-cell-specific promoters, such as the CD3ε locus. This approach aims to provide off-the-shelf, outpatient-applicable CAR-T therapy by bypassing the complexities of ex vivo manufacturing and preconditioning, while reducing the risks of random genomic integration and insertional mutagenesis associated with traditional viral vectors.

Other names

Protein Delivery Vehicle-DNA