Drug intelligence / Profile preview

Pediacel

Development stage
Approved
Lead developer
Sanofi Pasteur
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Pediacel is a pentavalent combination vaccine developed by Sanofi Pasteur for the active immunization of infants and children. It provides protection against five major pediatric diseases: diphtheria, tetanus, pertussis (whooping cough), poliomyelitis, and invasive disease caused by *Haemophilus influenzae* type b (Hib). The vaccine formulation includes diphtheria and tetanus toxoids, a five-component acellular pertussis (aP) component (pertussis toxoid, filamentous haemagglutinin, pertactin, and fimbriae types 2 and 3), inactivated poliovirus (IPV) types 1, 2, and 3, and Hib capsular polysaccharide (polyribosylribitol phosphate) conjugated to tetanus protein. It was a standard component of the United Kingdom's primary immunization schedule, typically administered at 2, 3, and 4 months of age, before being replaced by hexavalent vaccines.

Brand names
Pediacel
Other names
DTaP-IPV/Hib vaccinediphtheria, tetanus, acellular pertussis, inactivated poliomyelitis and Haemophilus influenzae type b conjugate vaccine
02

Targets

CD4+ T-cell receptor specific for Pediacel-derived peptide–MHC class II complexMHC II (Major histocompatibility complex class II receptor)BCR (Immunoglobulin G B Cell Receptor)

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