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PEG-eSDH
- Development stage
- Preclinical
- Lead developer
- University of Texas at Austin
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous, Subcutaneous
01
Overview
PEG-eSDH is a PEGylated, engineered variant of the human serine dehydratase (SDH) enzyme designed to deplete systemic levels of the amino acid serine. It is being investigated as a therapeutic strategy for hematologic malignancies, particularly Acute Myeloid Leukemia (AML) characterized by serine auxotrophy. This auxotrophic state is frequently driven by the epigenetic suppression of phosphoserine aminotransferase 1 (PSAT1), an enzyme in the serine synthesis pathway. By enzymatically degrading plasma serine, PEG-eSDH deprives these cancer cells of an essential external nutrient source, leading to reduced leukemia progression. The drug was developed through a collaboration involving researchers at the University of Texas at Austin and Johns Hopkins University.
- Other names
- PEGylated engineered human serine dehydratase
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