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peg-paclitaxel
- Development stage
- Discontinued
- Modality
- Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Peg-paclitaxel is a polymer–drug conjugate in which paclitaxel is covalently linked to polyethylene glycol (PEG) to improve solubility, circulation time, and tumor delivery compared with conventional paclitaxel. Paclitaxel’s antineoplastic mechanism is retained: it binds β-tubulin, stabilizes microtubules, disrupts dynamic instability, arrests cells in G2/M, and induces apoptosis; PEGylation serves as a delivery modification rather than altering the intrinsic target pharmacology.[1][2][7] Research and patents describe PEG as a solubilizing/stabilizing excipient or covalent carrier for paclitaxel to enable parenteral administration and potentially reduce Cremophor-related hypersensitivity; these PEG-based approaches aim to enhance exposure and tumor uptake of paclitaxel.[8][4]
- Other names
- polyethylene glycol–paclitaxel conjugate
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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