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pegademase bovine
- Development stage
- Unknown
- Lead developer
- Enzon Pharmaceuticals
- Modality
- Replacement Enzymes → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
Pegademase bovine is a modified form of the enzyme adenosine deaminase (ADA) derived from bovine sources and conjugated with polyethylene glycol (PEG) to extend its half-life in circulation. It is used as an enzyme replacement therapy for severe combined immunodeficiency disease (SCID) associated with ADA deficiency. The drug works by replacing the missing or deficient ADA enzyme, thereby reducing toxic levels of adenosine and 2'-deoxyadenosine that accumulate in patients with ADA deficiency and are harmful to lymphocytes. This correction helps restore immune function over time, although improvement may take weeks to months. Pegylation reduces immunogenicity and prolongs the duration of action[1][2][4][5][6][8].
- Brand names
- Adagen
- Other names
- pegademasepegylated bovine adenosine deaminase
02
Targets
ADA (Adenosine deaminase)
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